Publications | rtcure

Publications from the RTCure Team

Baker, K. F., Sim, J. P., and Isaacs, J. D. (2021). Biomarkers of tolerance in immune-mediated inflammatory diseases: a new era in clinical management? The Lancet Rheumatology. 3(5): e371-e382.

Toes, R. E. and Raza, K. (2021). The autoimmune response as a potential target for tolerance induction before the development of rheumatoid arthritis. The Lancet Rheumatology. 3(3): e214-e223.

Panda, S. K., Wigerblad, G., et al. (2020). IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints. Proceedings of the National Academy of Sciences. 117(6): 3103-3113.

Bertolo, M., Baumgart, S., et al. (2020). Deep phenotyping of urinary leukocytes by mass cytometry reveals a leukocyte signature for early and non-invasive prediction of response to treatment in active lupus nephritis. Frontiers in immunology. 11: 256.

Bibby, J. A., Purvis, H. A., et al. (2020). Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate. Nature communications. 11(1): 1-12.

Cornelis, R., Hahne, S., et al. (2020). Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial-and ER Stress Induced Death of Memory Plasma Cells. Cell reports. 32(5): 107982.

Gerstner, C., Turcinov, S., et al. (2020). Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis. BMC immunology. 21: 1-14.

Kissel, T., Reijm, S., et al.. (2020). Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications. Annals of the rheumatic diseases. 79(4): 472-480.

Mosor, E., Stoffer‐Marx, M., et al. (2020). I would never take preventive medication! Perspectives and information needs of people who underwent predictive tests for rheumatoid arthritis. Arthritis care & research. 72(3): 360-368.

Nel, H. J., Malmström, V., Wraith, D. C. and Thomas, R. (2020). Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy. The Lancet Rheumatology. 2(11): e712-e723.

Reed, E., Hedström, A. K., Hansson, M., et al. (2020). Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity. Arthritis research & therapy. 22(1): 1-11.

Roos Ljungberg, K., Joshua, V., et al.. (2020). Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis. Rheumatology. 59(4): 852-859.

Sahlström, P., Hansson, M., et al. (2020). Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis. Arthritis & Rheumatology. 72(10): 1643-1657.

Stanway, J. A. and Isaacs, J. D. (2020). Tolerance-inducing medicines in autoimmunity: rheumatology and beyond. The Lancet Rheumatology. 2(9): e565-e575.

Steffen, U., Koeleman, C. A., et al. (2020). IgA subclasses have different effector functions associated with distinct glycosylation profiles. Nature communications. 11(1): 1-12.

Tajik, N., Frech, M., et al. (2020). Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nature communication. 11(1): 1-14.

Bonelli, M., Dalwigk, K., et al. (2019). IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes. Experimental & molecular medicine. 51(7): 1-11.

Budzinski, L., Schulz, A. R., Baumgart, S., Burns, T., Rose, T., Hirseland, H., and Mei, H. E. (2019). Osmium-labeled microspheres for bead-based assays in mass cytometry. The Journal of Immunology. 202(10): 3103-3112.

Chemin, K., Gerstner, C. and Malmström, V. (2019). Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation—Lessons From Rheumatoid Arthritis. Frontiers in immunology. 10: 353.

Cope, A. P. (2019). Considerations for optimal trial design for rheumatoid arthritis prevention studies. Clinical therapeutics. 41(7): 1299-1311.

Cossarizza, A., Chang, H. D., et al. (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European journal of immunology. 49(10): 1457-1973.

Eriksson, K., Fei, G., et al. (2019). Periodontal health and oral microbiota in patients with rheumatoid arthritis. Journal of clinical medicine. 8(5): 630.

Goncalves-Alves, E., Saferding, V., et al. (2019). MicroRNA-155 controls T helper cell activation during viral infection. Frontiers in immunology. 10: 1367.

Hafkenscheid, L., de Moel, E., et al. (2019). N‐linked glycans in the variable domain of IgG anti–citrullinated protein antibodies predict the development of rheumatoid arthritis. Arthritis & Rheumatology. 71(10): 1626-1633.

Hradilkova, K., Maschmeyer, P., et al. (2019). Regulation of fatty acid oxidation by Twist 1 in the metabolic adaptation of T helper lymphocytes to chronic inflammation. Arthritis & Rheumatology. 71(10): 1756-1765.

Kampstra, A. S. B., Dekkers, J. S., et al. (2019). Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification. Annals of the rheumatic diseases. 78(7): 908-916.

Kampylafka, E., Simon, D., et al. (2019). Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation—data from the prospective IVEPSA study. Arthritis research & therapy. 21(1): 1-9.

Kissel, T., van Schie, K. A., et al. (2019). On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis. Annals of the rheumatic diseases. 78(12): 1616-1620.

López-Serrano Oliver, A., Haase, A., et al.. (2019). Mass cytometry enabling absolute and fast quantification of silver nanoparticle uptake at the single cell level. Analytical chemistry. 91(18): 11514-11519.

Németh, T., Futosi, K., Szabó, M., Aradi, P., Saito, T., Mócsai, A. and Jakus, Z. (2019). Importance of Fc receptor γ-chain ITAM tyrosines in neutrophil activation and in vivo autoimmune arthritis. Frontiers in immunology. 10: 252.

Perucha, E., Melchiotti, R., et al. (2019). The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells. Nature communications. 10(1): 1-13.

Schulz, A. R., Baumgart, S., Schulze, J., Urbicht, M., Grützkau, A. and Mei, H. E.(2019). Stabilizing antibody cocktails for mass cytometry. Cytometry Part A. 95(8): 910-916.

Simon, D., Kleyer, A., Bayat, S., et al. (2019). Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients. Arthritis research & therapy. 21(1): 1-8.

Steffen, U., Andes, F. T. and Schett, G. (2019). Generation and analysis of human and murine osteoclasts. Current protocols in immunology. 125(1): e74.

Spiering, R., Jansen, M. A., et al. (2019). Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis. Journal of translational medicine. 17(1): 1-12.

Sun, M., Rethi, B., et al. (2019). Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts. Annals of the rheumatic diseases. 78(12): 1621-1631.

Terao, C., Brynedal, B., et al. (2019). Distinct HLA associations with rheumatoid arthritis subsets defined by serological subphenotype. The American Journal of Human Genetics. 105(3): 616-624.

Vergroesen, R. D., Slot, L. M., Van Schaik, B. D., Koning, M. T., Rispens, T., Van Kampen, A. H., René, E. M. and Scherer, H. U. (2019). N-glycosylation site analysis of citrullinated antigen-specific B-cell receptors indicates alternative selection pathways during autoreactive B-cell development. Frontiers in immunology. 10: 2092.

Wang, Y., Lloyd, K. A., et al. (2019). Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance. Scientific reports. 9(1): 1-13.

Wehr, P., Purvis, H., Law, S. C. and Thomas, R. (2019). Dendritic cells, T cells and their interaction in rheumatoid arthritis. Clinical & Experimental Immunology. 196(1): 12-27.

Wohlfahrt, T., Rauber, S., et al. (2019). PU. 1 controls fibroblast polarization and tissue fibrosis. Nature. 566(7744): 344-349.

Alexander, T., Cheng, Q., et al. (2018). Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors. European journal of immunology. 48(9): 1573-1579.

Bozec, A., Luo, Y., Engdahl, C., Figueiredo, C., Bang, H. and Schett, G. (2018). Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner. Arthritis research & therapy. 20(1):1-9.

Csepregi, J. Z., Orosz, A., et al. (2018). Myeloid-specific deletion of Mcl-1 yields severely neutropenic mice that survive and breed in homozygous form. The Journal of Immunology. 201(12): 3793-3803.

Engdahl, C., Bondt, A., et al. (2018). Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women. Arthritis research & therapy. 20(1): 1-11.

Fischer, A., Abdollahi‐Roodsaz, S., et al. (2018). The involvement of Toll‐like receptor 9 in the pathogenesis of erosive autoimmune arthritis. Journal of cellular and molecular medicine. 22(9): 4399-4409.

Lelieveldt, L. P., Kristyanto, H., Pruijn, G. J., Scherer, H. U., Toes, R. E., and Bonger, K. M. (2018). Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells. Molecular pharmaceutics. 15(12): 5565-5573.

Neumann, A., Haschka, J., et al. (2018). Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis. Arthritis research & therapy. 20(1): 1-11.

Sieghart, D., Platzer, A., et al. (2018). Determination of autoantibody isotypes increases the sensitivity of serodiagnostics in rheumatoid arthritis. Frontiers in immunology. 9:876.

Simon, D., Kleyer, A., et al. (2018). Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis-effects of age and disease duration. Arthritis research & therapy. 20(1): 1-9.

Stemmler, F., Simon, D., Liphardt, A. M., Englbrecht, M., Rech, J., Hueber, A. J ., Engelke, K., Schett, G. and Kleyer, A. (2018). Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures. Annals of the rheumatic diseases. 77(7): 973-980.

Cope, A. P. (2017). Emerging therapies for pre-RA. Best Practice & Research Clinical Rheumatology. 31(1), 99-111.